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Bachelor of Sciences -> Diploma in Bioinformatics -> 1 year-> 2nd Semester   Proteomics/Molecular Modeling Paper 8 Proteomics/Molecular modeling Unit 1 : Protein sequencing 1.1 Protein sequencing by Edman degradation 1.2 Protein sequencing by mass spectrometry Unit 2 : Introduction to Interesting bio-molecular modeling problems 2.1 Protein folding 2.2 Protein mis folding 2.3 Nucleic acid / protein interaction 2.4 Computational and theoretical approaches to structure prediction 2.5 Overview of Ram Chandran plot Unit 3 : Structural Bio-informatics 3.1 Proteing structure analysis 3.2 Conceptual models of protein structure 3.3 Relationship of protein three-dimensional structure to protein function 3.4 Obtaining, viewing and analyzing structural data structural alignment Unit 4 : Classification of proteins of known three- Dimensional structure: CATH and SCOP 4.1 Introduction to protein structure prediction 4.2 Structure prediction by comparative prediction 4.3 Secondary structure prediction 4.4 Tertiary structure prediction 4.5 Advanced protein structure prediction and prediction strategies Unit 5 : High Order Systems 5.1 Modeling a molecule 5.2 Reconstruction of molecular pathways 5.3 Protein interaction informatics 5.4 Higher order molecules Molecular Modeling Practicals 1. Protein resources by using Entrenz and mode 2. Secondary structure prediction 3. Tertiary structure prediction 4. Searching of domains using protons 5. Mode of searching

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