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Bachelor of Sciences -> Diploma in Bioinformatics -> 1 year-> 2nd Semester   Genomics Paper 7 GENOMICS Unit 1 : Genomics and the Genome Project 1.1 Genomics 1.2 Genome Sequencing 1.3 Raw genome sequence data, Expressed sequence tags and sequence tag sites 1.4 DNA chip 1.5 Comparative genomics 1.6 Functional genomics 1.7 The Genome annotation problem 1.8 The genome project and internet Unit 2 : Similarity Searching 2.1 Introduction to sequence similarity 2.2 Dot plots matrix,Distance matrix 2.3 Similarity searches on the world wide web 2.4 FASTA 2.5 BLAST Unit 3 : Pair wise and multiple alignment 3.1 Introduction to alignment 3.2 Global variables and local 3.3 Phylogenetics – cladistic and ontology 3.4 Evolution of macro molecules sequence Unit 4 : Sequence annotation 4.1 Pronciples of genome annotation 4.2 Annotation Tools and resources 4.3 Restriction mapping tools 4.4 Mec Vector and OMIGA 4.5 Gene construction kit 4.6 Primer design programs Unit 5 : Genome annotation 5.1 Finding genes by computer 5.2 Open reading frames 5.3 Detecting exams & introns 5.4 Gene prediction software 5.5 Neural not algorithms 5.6 Markov model algorithms Genomics Practicals 1. Genome information resource from websites a. Overview of NCBI & Genbank b. Overview of NCBI & EBI c. Overview of NCBI & DDBJ 2. Browse through the genome database of human genome, E-Col and yeast 3. Express the genome in terms of Base pairs, Chromosomes ( Highest Chromosome size, lowest chromosome size) and even each chromosome database size 4. Downloading related sequence using retrieve (Entry SRS) 5. ORF finding tools & find the Exons and introns

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